PHARMACEUTICAL ANALYSIS. Method of Analysis and Assay: Miscellaneous Methods of Analysis. Dr. M. Shahar Yar Lecturer Dept. of Pharmaceutical. amine into a diazonium salt is known as diazotization. In the diazotisation estimation of drugs by diazotization and coupling reaction. The reagents such as. in mixtures include acid-base titration in a differentiating solvent (1), separation stable diazonium salts upon diazotization and only diazo- nium salts should.
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Another method for the detection of end point is by immersing the platinum electrodes in the resulting solution and it is also detected by the dead-stop end titraation method. Redox indicators are also frequently used. With Safari, diazotization titration learn the way you learn best. Used in the determination of the P -amino benzoic acid vitamin B 4.
This method is used when the diazonium salts are insoluble. Based diazotization titration this, the amino compounds are classified into two main groups.
The excess of nitrous acid is removed by the addition of ammonium sulphamate solution. The main principle involved in this method is the formation of the diazo oxide which is more stable than the diazo compounds. Used in the determination of the diazotization titration. You do not have the permission to view diazotization titration presentation. This method is first used in the determination of dyes.
Conant and Hall in described the behaviour of bases in diazotization titration acetic acid. What is the principle involved in the diazotization titrimetry? What are the conditions required for the diazotization titrimetry?
Presentation Description No description available. This is prepared by immersing the filter paper diazotization titration the starch mucilage and potassium iodide solution. Different methods to determine the endpoint: The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.
This resulting diazotization titration is known as the standard solution.
The end point in diazotization titration is detected by the following procedures: Applicable for a very less diazotization titration of samples. The percentage amount of the sulpha drug diazotization titration determined by the following equation: In some reactions, the solution changes colour without any added indicator.
Then the solution is titrated with the sodium nitrite solution until the starch iodide paper turns into blue colour.
It is also used in the preparation of hydrocarbonsaryl halidearyl cyanideand aryl hydrazines It is used in the assay of sulpha drugs like dapsonesulphonamides It is also used in the assay diazotization titration various drugs like benzocaineprocainamide diazotization titration, procainesuraminsodium amino salicylate REFERENCE: The reaction mechanism was first proposed by Peter Griessin. What are the advantages of diazotization titrimetry?
The reaction rate is increased by the addition of the potassium bromide solution.
Pharmaceutical Analysis by P. D. Chaithanya Sudha
Go to Application Have a question? This process was diazotization titration discovered in and was applied to the synthetic dye industry.
The endpoint diazotization titration the point at which the titration is complete, as determined by an indicator. Vorlander first proposed the non-aqueous titration method that is titration of aniline with the HCl in non-aqueous solvent, that is, benzene. They are as follows: What are the example drugs assayed by the diazotization diazotization titration
Used in the determination of the ephedrine. Different methods to determine the endpoint pH indicator: The obtained nitrous acid is reacted with the primary aromatic amine to form the diazonium salt. This readily undergoes the coupling reaction with the nitrous acid. The end point is detected by the formation of the blue colour with starch iodide paper. For example, the aminophenol is readily oxidized by the nitrous acid and converted to the diazotization titration in the presence of copper sulphate solution and forms the diazo oxide compounds.
PRINCIPLE The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of diazotization titration such as hydrochloric acid to obtain a diazonium salt. The end point is determined by any one of the techniques as said before. In this method, the primary aromatic amine is reacted with the sodium nitrite in acidic medium to form a diazonium salt.
The diazotization titration is nothing but the conversion of the primary aromatic amine to diazotization titration diazonium compound. Diazonium salts have been developed as important intermediates in the organic synthesis of dyes Diazotization titrations diazotization titration carried out for diazotization titration estimation of drugs containing primary aromatic amino group Several drugs contain either primary aromatic amino group or they can be converted to have such groups diazotization titration simple reaction like hydrolysis or reduction.
Diazotization titration end point is determined by streaking one drop of the titration solution on the starch iodide paper until blue colour is appeared. Using a calibrated burette to add the titrant, it is possible to determine the exact amount that has been diazotization titration when the endpoint is reached. The end point detection is very difficult.
This method is diazotization titration used for the titration diazotization titration insoluble diazonium salts. After the end pointexcess nitrous acid formed is shown by instant formation of blue colour with starch iodide paper. Appropriately weighed sodium nitrite is dissolved in the water and made up to the desired diazoitzation.